2-Butoxyethanol enhances the adherence of red blood cells.

摘要: We recently presented a unique, chemically-induced rat model of hemolytic anemia and disseminated thrombosis. In this 2-butoxyethanol (BE)-induced the organs developing infarction are comparable to those seen in human diseases, characterized by hemolysis thrombosis (e.g., thalassemia, sickle-cell disease, paroxysmal nocturnal hemoglobinuria, intravascular coagulation, thrombotic thrombocytopenic purpura, uremic syndrome). Red blood cells (RBCs) have special flow properties, namely, self-aggregability, deformability, potential adherence endothelial (ECs) vessel wall, which essential for adequate tissue perfusion; their alteration facilitates circulatory disorders. To examine possible contribution alterations RBC properties observed present investigation we determined BE-induced changes adherence, aggregability, deformability RBCs from male female Fischer F344 rats exposed two, three, or four daily doses BE at 250 mg BE/kg body weight. Control animals were treated with vehicle alone. Blood was taken on days 2, 3, 4, 29. The administration did not affect aggregability but markedly enhanced extracellular matrix; such enhancement correlated cultured ECs. RBC/EC interaction has been shown be potent catalyst vascular occlusion hemoglobinopathies; thus EC is likely mechanism organ infarct induced BE-treated rats.