Intervention in the Context of Development: Pathways Toward New Treatments

摘要: Neuropsychiatric disorders vary substantially in age of onset but are best understood within the context neurodevelopment. Here, we review opportunities for intervention at critical points developmental trajectories. We begin by discussing potential to prevent neuropsychiatric disorders. Once symptoms emerge, a number interventions have been studied either before diagnosis can be made or shortly after diagnosis. Although some these helpful, few based upon an understanding pathophysiology, and most ameliorate rather than resolve symptoms. As such, next portion review, turn our discussion genetic syndromes that rare phenocopies common diagnoses such as autism spectrum disorder schizophrenia. Cellular animal models point specific regulatory signaling pathways. examples, findings from mouse Fragile X Rett treatments now being tested randomized clinical trials. Paralleling oncology, hope will move nonspecific, like chemotherapies thrown wide range tumor types, specific, protein kinase inhibitors target molecularly defined tumors. Some targeted later show benefit broader, yet array cancers. medications developed neurodevelopmental similarly help subgroups patients with disruptions overlapping The insights gleaned treatment development phenocopy may also teach us how test emerging environmental risk factors.