Locally advanced thyroid cancer: therapeutic options.

摘要: Abstract The authors report on their experience in the management of thyroid cancer, with specific regard to advanced disease. Thyroid carcinomas behave differently according to: pathology, sex, age, grading and size. Differentiated lesions have a favourable outlook, while for less-differentiated tumours prognosis is dismal. Extent resection, lymphectomy technique disease remain matters debate. Of particular interest are those neoplasms invading upper aerodigestive tract, characterised by worse case differentiated (1-6%), indicating an exceedingly aggressive behaviour what usually slowly evolving Surgery, curative intent or palliation, mandatory. tumour progressively invades tracheal lumen seldom manageable alternative, non-surgical methods, any only short periods time. Total thyroidectomy resection anastomosis surgical choice and, when combined radiometabolic therapy and/or external radiotherapy, yields survival data comparable relating less lesions. Tracheal stents tracheotomy improve quality life. Laser indicated cases asphyxia, as preliminary step view subsequent radical palliative treatments.