Systematic analysis of neuronal wiring of the rodent deep cerebellar nuclei reveals differences reflecting adaptations at the neuronal circuit and internuclear levels.

摘要: A common view of the architecture different brain regions is that, despite their heterogeneity, they have optimized wiring schemes to make maximal use space. Based on experimental findings, computational models delineated how about two-thirds neuropil filled out with dendrites and axons optimizing cable costs conduction time while keeping connectivity at highest level. However, whether this assumption can be generalized all has not yet been tested. Here we quantified charted components in four deep cerebellar nuclei (DCN) rat's brain. We segmented traced stained one two antibodies, antibody against dendritic microtubule-associated proteins (MAP2a,b) second Purkinje cell (PCP2). compared fiber length density, average diameter, volume fraction within DCN a random, systematic fashion. observed differences axonal diameters, that up DCN. observe relative increase density DCN, namely, posterior interposed nucleus lateral nucleus. Furthermore, surprisingly low which propose related special circuitry. In summary, our results show previously unappreciated functional adaptations among these nuclei. J. Comp. Neurol. 522:2481–2497, 2014. © 2014 Wiley Periodicals, Inc.