Assessing modulators of cytochrome c oxidase activity in Galleria mellonella larvae.
作者： Kristin L. Frawley , Hirunwut Praekunatham , Andrea A. Cronican , Jim Peterson , Linda L. Pearce
DOI: 10.1016/J.CBPC.2019.02.009
关键词: Proleg 、 Cyanide 、 Sodium azide 、 Biochemistry 、 Toxicant 、 Sodium 、 Galleria mellonella 、 Mitochondrion 、 Chemistry 、 Sodium cyanide
摘要: Abstract Caterpillars of the greater wax moth, Galleria mellonella, are shown to be a useful invertebrate organism for examining mitochondrial toxicants (inhibitors electron transport) and testing putative antidotes. Administration sodium azide, cyanide, or (hydro)sulfide by intra-haemocoel injection (through proleg) results in dose-dependent paralysed state larvae lasting from
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