The Role of Calcium, Magnesium, and Zinc in Carcinogenesis

摘要: The effects of calcium, magnesium, and zinc supplementation magnesium depletion on carcinogenesis are comprehensively reviewed, including epidemiologic experimental investigations. Some data the neoplasia homeostasis these metals also presented. Despite many conflicting results, this review reveals that (1) calcium is more likely to enhance than inhibit chemical carcinogenesis; (2) or tends (3) deficiency increases incidence in humans animals; (4) parenteral administration along with a carcinogen produces local anticarcinogenic effects, while zinc’s activity be systemic; (5) there simple correlation between inhibition by reduction binding cells DNA. mechanisms not clear. They may involve molecular interactions metal at different enzymatic regulatory sites target undergoing neoplastic transformation, as well stimulation host immune system.