Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats

摘要: Background and aims: Crohn’s disease, characterised by chronic T helper 1 (Th1) inflammation dysmotility of the gut, is most prevalent in developed countries. Parasitic infections are developing countries induce a 2 (Th2) immune response. We hypothesised that this Th2 response protects against Th1 gut inflammation. Methods: The parasite Schistosoma mansoni induces transient semipermissive rat host. 2,4,6-Trinitrobenzene sulphonic acid (TNBS) induced colitis an experimental model Th1-like effect concurrent infection with S on course TNBS was assessed using macroscopic microscopic damage scores, histology, myeloperoxidase (MPO) activity assay, cytokine production studying vitro contractility longitudinal circular colonic muscle strips. Results: spontaneously healed after four weeks. Concurrent significantly reduced duration to two weeks, as shown scores faster decrease MPO activity. increased interleukin (IL-2) whereas splenic IL-4 IL-2 levels. Contractility strips maximally inhibited one week normalised three After strip increased. remained inhibited. Conclusions: attenuates rat. Inflammation disturbances may outlast inflammatory reaction.