Multicenter Laboratory Validation of the BACTEC MGIT 960 Technique for Testing Susceptibilities of Mycobacterium tuberculosis to Classical Second-Line Drugs and Newer Antimicrobials
作者： S. Rusch-Gerdes , G. E. Pfyffer , M. Casal , M. Chadwick , S. Siddiqi
DOI: 10.1128/JCM.44.3.688-692.2006
关键词: Linezolid 、 Ethionamide 、 Mycobacterium tuberculosis 、 Capreomycin 、 Drug 、 Medicine 、 Ofloxacin 、 Rifabutin 、 Microbiology 、 Amikacin
摘要: The BACTEC MGIT 960 system, a fully automated, nonradiometric, noninvasive system for detection and drug susceptibility testing of mycobacteria, was evaluated the ability to test susceptibilities second-line drugs. In this study, which carried out in three phases (phase I, mostly susceptible strains; phase II, resistant III, final optimal concentrations found I II), we established critical seven drugs be tested compared 460TB system. used are as follows: amikacin, 1.0 μg/ml; capreomycin, 2.5 ethionamide, 5.0 protionamide, ofloxacin, 2.0 rifabutin, 0.5 linezolid, μg/ml. Our results demonstrate that is an accurate method rapid Mycobacterium tuberculosis
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