Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma

摘要: Background The presence of regional lymph node metastasis has an important impact on clinical management and prognostication patients with oral tongue squamous cell carcinoma (SCC). Approximately 30% to 50% SCC have at diagnosis, but the limited sensibility current diagnostic methods used for neck staging does not allow detection all cases, leaving a significant number undiagnosed (occult metastasis). In this study, we evaluated whether clinicopathologic features immunohistochemical carcinoma-associated fibroblasts (CAFs) activin A could be predictive markers occult in SCC. Methods One hundred ten primary SCC, who were classified early stage tumor (stage I II) received surgical treatment elective dissection, enrolled study. Results Among examined features, only high expression was significantly associated (p = .006). Multivariate survival analysis using Cox proportional hazard model showed that independent marker reduced overall 5-year 89.7% low compared 76.5% those (hazard ratio [HR], 2.44; 95% confidence interval [CI], 1.55–3.85; p = .012). Conclusion Our results demonstrated immunodetection can useful revealing lower survival. © 2014 Wiley Periodicals, Inc. Head Neck 37: 479–486, 2015