Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment

摘要: Major changes in intra- and extracellular pH homoeostasis are shared features of most solid tumours. These stem large part from the metabolic shift cancer cells towards glycolytic metabolism other processes associated with net acid production. In combination oncogenic signalling impact factors tumour microenvironment, this upregulates acid-extruding plasma membrane transport proteins which maintain intracellular normal or even more alkaline compared that cells, while turn acidifying external microenvironment. Mounting evidence strongly indicates contributes significantly to development by favouring e.g. cell migration, invasion chemotherapy resistance. Finally, still under-explored, it seems likely non-cancer microenvironment also exhibit altered regulation may contribute their malignant properties. Thus, physical stromal within undergo important reciprocal interactions modulate profile, severely impacting on course progression. Here, we summarize recent knowledge placing context regulation, discuss how interfering these properties be exploited clinically.