Proteinuria and mortality in diabetes: the WHO Multinational Study of Vascular Disease in Diabetes.
作者： JM Stephenson , S Kenny , LK Stevens , JH Fuller , E Lee
DOI: 10.1111/J.1464-5491.1995.TB00446.X
关键词: Risk factor 、 Type 1 diabetes 、 Heavy proteinuria 、 Diabetes mellitus 、 Surgery 、 Vascular disease 、 Internal medicine 、 Type 2 diabetes 、 Nephropathy 、 Medicine 、 Proteinuria
摘要: The relation between proteinuria and mortality was investigated in 1188 patients with Type 1 diabetes 3234 2 diabetes, aged 35-55 at baseline followed up for a mean of 9.4 +/- 3.1 years the WHO Multinational Study Vascular Disease Diabetes. Baseline prevalence light or heavy same (25 %) both types after adjustment differences duration. Compared no proteinuria, all cause ratios were 1.5 (95 % confidence interval 1.1-2.0) 2.9 (2.2-3.8) respectively, (1.2-1.8) 2.8 (2.3-3.4) patients, age, duration blood pressure, cholesterol, smoking. Proteinuria associated significantly increased from renal failure, cardiovascular disease, other causes death. In association strongest deaths, similar magnitude conclusion, is common, important, rather non-specific risk factor morbidity diabetes. to benefits risks reduction should be examined large randomized trials clinical endpoints.
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