Automated recognition of atypical nuclei in breast cancer cytology specimens by iterative image transformations
作者： C. J. Cornelisse , A. M. J. Driel-Kulker , F. Meyer , J. S. Ploem
DOI: 10.1111/J.1365-2818.1985.TB02566.X
关键词: Nuclear atypia 、 Image transformation 、 Breast cancer 、 Cytology 、 Mathematical morphology 、 Segmentation 、 Radiology 、 Pathology 、 Nuclear area 、 Biology 、 Cytophotometry
摘要: In order to develop an objective grading system for nuclear atypia in breast cancer, image analysis technique has been applied the automated recognition of enlarged and hyperchromatic nuclei cytology specimens. The segmentation algorithm, based on 'top hat' transformation developed mathematical morphology, is implemented LEYTAS microscope system. performance algorithm evaluated fifty malignant eighty-five benign lesions by visual inspection displayed 'flagged' objects. mean number flagged objects per 1600 fields cancers was 887 (range 0-7920) which 87% consisted single, atypical nuclei. For 30 0-307) 20% were single By adaptation parameter values, a more extreme subpopulation could be discriminated. large interspecimen variation cancer results related differences DNA content distribution area, determined independently with scanning cytophotometry, some extent histological type.
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sci-hub.se 参考文章(13)
H J G Bloom, W W Richardson, Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. British Journal of Cancer. ,vol. 11, pp. 359- 377 ,(1957) , 10.1038/BJC.1957.43
Ewert Bengtsson, Jan Vegelius, Sighild Westman-Naeser, Jan Holmquist, Olle Eriksson, Bo Nordin, Björn Stenkvist, Cecil H. Fox, Computerized Nuclear Morphometry as an Objective Method for Characterizing Human Cancer Cell Populations Cancer Research. ,vol. 38, pp. 4688- 4697 ,(1978)
Lars L. Vindeløv, Ib J. Christensen, Nis I. Nissen, A Detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis† Cytometry. ,vol. 3, pp. 323- 327 ,(1983) , 10.1002/CYTO.990030503
Björn Stenkvist, Ewert Bengtsson, Olle Eriksson, Torsten Jarkrans, Bo Nordin, A morphometric expression of differentiation in fine-needle biopsies of breast cancer† Cytometry. ,vol. 1, pp. 292- 295 ,(1981) , 10.1002/CYTO.990010409
L J van Bogaert, C de Muylder, P Maldague, H Maisin, Prognostic Implications of Mean Nuclear Diameter in Breast-cancer British Journal of Cancer. ,vol. 42, pp. 537- 541 ,(1980) , 10.1038/BJC.1980.277
H J Tanke, E M van Ingen, J S Ploem, Acriflavine-Feulgen stilbene staining: a procedure for automated cervical cytology with a television based system (LEYTAS). Journal of Histochemistry and Cytochemistry. ,vol. 27, pp. 84- 86 ,(1979) , 10.1177/27.1.86584
B Stenkvist, S Westman-Naeser, J Vegelius, J Holmquist, B Nordin, E Bengtsson, O Eriksson, Analysis of reproducibility of subjective grading systems for breast carcinoma. Journal of Clinical Pathology. ,vol. 32, pp. 979- 985 ,(1979) , 10.1136/JCP.32.10.979
Wlodzimierz Olszewski, Zbigniew Darzynkiewicz, Paul Peter Rosen, Morton K. Schwartz, Myron R. Melamed, Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor Cancer. ,vol. 48, pp. 980- 984 ,(1981) , 10.1002/1097-0142(19810815)48:4<980::AID-CNCR2820480421>3.0.CO;2-7
Björn Stenkvist, Ewert Bengtsson, Bengt Dahlqvist, Gunnar Eklund, Olle Eriksson, Torsten Jarkrans, Bo Nordin, Predicting breast cancer recurrence Cancer. ,vol. 50, pp. 2884- 2893 ,(1982) , 10.1002/1097-0142(19821215)50:12<2884::AID-CNCR2820501231>3.0.CO;2-K
F Meyer, Iterative image transformations for an automatic screening of cervical smears. Journal of Histochemistry and Cytochemistry. ,vol. 27, pp. 128- 135 ,(1979) , 10.1177/27.1.438499