Blood plasma lipidomic signature of epicardial fat in healthy obese women.

摘要: ObjectivesA lipidomic approach was employed in a clinically well-defined cohort of healthy obese women to explore blood lipidome phenotype ascribed body fat deposition, with emphasis on epicardial adipose tissue (EAT). MethodsThe present investigation delivered lipidomics signature adiposity under clinical conditions using 40 females (age: 25-45 years, BMI: 28-40 kg/m(2)) not showing any metabolic disease traits. Lipidomics analysis plasma combination vivo quantitation mediastinal depots by computerized tomography. ResultsAll cardiac correlated indicators hepatic dysfunctions (ALAT and ASAT), which describe physiological connections between steatosis. Plasma encompassed overall levels lipid classes, fatty acid profiles, individual species. EAT visceral associated diacylglycerols (DAG), triglycerides, distinct phospholipid sphingolipid A pattern DAG phosphoglycerols specific EAT. ConclusionsHuman appears be promising potentially diagnostic readout for patient stratification monitoring. Association regio-specific may help provide more biological insights into cardiovascular risks.