Detection of Melanoma Cancer Biomarker Dimethyl Disulfide Using Cavity Ringdown Spectroscopy at 266 nm.
作者： Zhennan Wang , Meixiu Sun , Chuji Wang
关键词: Melanoma cancer 、 Spectroscopy 、 Cavity ring-down spectroscopy 、 Analytical chemistry 、 Dimethyl disulfide 、 Mass spectrometry 、 Laser 、 Parts-per notation 、 Detection limit 、 Chemistry
摘要: Skin cells emit volatile organic compounds (VOCs), and some of them can be used as biomarkers for screening specific diseases. Dimethyl disulfide (DMDS) has been recently reported a biomarker melanoma skin cancer (Kwak et al. "Volatile Biomarkers from Human Melanoma Cells". J. Chromatogr. B. 2013. 931: 90-96.). With the motivation diagnosing using DMDS its biomarker, we explore potential measuring an advanced laser spectroscopic technique alternative method. We report on first measurements experimental system based cavity ringdown spectroscopy (CRDS). The test samples were mixtures vapor nitrogen in different concentrations. Two sampling methods investigated to dilute sample low concentrations measurements. results showed that responded various linearly theoretical detection limit sub-ppb (parts per billion) could achieved at absorption wavelength 266 nm. This exhibited high dynamic range measurements, ppm million) ppt trillion) levels, given wavelengths used. feasibility developing portable sensor CRDS was also demonstrated this study.
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