Biaryl ether derivatives useful as monoamine reuptake inhibitors

作者: Mavis Diane Adam , Harry Ralph Howard

DOI:

关键词: Reuptake inhibitorPharmacologyEtherCentral nervous systemChemistryNorepinephrineMonoamine neurotransmitterBiochemistrySerotonin

摘要: The present invention relates to compounds of formula (I) and their pharmaceutically acceptable salts. Compounds exhibit activity as serotonin, norepinephrine, dopanine reuptake inhibitors can be used in the treatment central nervous system other disorders.

参考文章(10)
Christopher Joseph Schmidt, Harry Ralph Howard, Mark Leonard Elliott, Thomas Francis Seeger, Monoamine reuptake inhibitors for treatment of cns disorders ,(2000)
Alan Stobie, David Hepworth, Mark David Andrews, Donald Stuart Middleton, Diphenyl ether compounds useful in therapy ,(2001)
Alexey V. Kalinin, Justin F. Bower, Peter Riebel, Victor Snieckus, The Directed Ortho Metalation−Ullmann Connection. A New Cu(I)-Catalyzed Variant for the Synthesis of Substituted Diaryl Ethers Journal of Organic Chemistry. ,vol. 64, pp. 2986- 2987 ,(1999) , 10.1021/JO990114X
Hans-Joachim Dr. Santel, Wilhelm Dr. Haas, Karl-Heinz Linker, Otto Dr. Schallner, Kurt Prof. Dr. Findeisen, Markus Dr. Dollinger, 1-aryltriazolin(ethi)ones ,(1994)
Zdene^¿k Polívka, Alexandra S^¿Ilhánková, Ivan Krejc^¿Í, Karel S^¿Indelár^¿, Ruz^¿ena Míc^¿Ková, Karel Dobrovsky, Vladimír Valenta, Derivates of n,n-dimethyl-2-(arylthio)benzylamine, their salts, methods of preparation and their use in pharmaceutical medicaments ,(1996)
Gerardus S. F. Ruigt, Dirk Leysen, Johannes H. Wieringa, Phenoxyphenyl derivatives, compositions and methods of use thereof ,(1992)
Ingo Wetcholowsky, Rolf Pontzen, Dieter Feucht, Karl-Heinz Linker, Mark Wilhelm Drewes, Otto Schallner, Joachim Kluth, Substituierte 3-Aryl-pyrazole ,(1999)
Ingo Wetcholowsky, Rolf Pontzen, Roland Andree, Mark Wilhelm Drewes, Hans-Georg Schwarz, Dieter Feucht, Karl-Heinz Linker, Otto Schallner, New aryl-substituted aza-heterocyclic compounds, useful as pre- or post-emergence, total or selective herbicides, show defoliant, dessicant and especially weed-killing activity ,(1999)
Laszlo Beregi, Pierre Hugon, Michelle Boulanger, Jacques Duhault, Phenoxy phenyl pyrrolidine compounds, compositions and methods of use ,(1978)