Role of Pyroptosis in Traumatic Brain and Spinal Cord Injuries.

摘要: Central nervous system (CNS) trauma, including traumatic brain injury (TBI) and spinal cord (SCI), remains a leading cause for morbidity mortality worldwide. Past research has shown that cell death plays critical role in the pathophysiology of CNS injuries. More recently, pyroptosis been identified as form programmed inflammatory death, it is unique various aspects. Mechanistically, can be categorized into canonical (mediated by caspase-1) non-canonical caspase-4/5/11). In pyroptosis, Nod-like receptors (NLRs) inflammasomes play role, their activation promotes maturation secretion cytokines interleukin-1β/18 (IL-1β/18), cleavage gasdermin D (GSDMD), ultimately pyroptotic death. Despite plethora new knowledge regarding detailed understanding how involved injuries possible ways to improve clinical outcomes following remain elusive. This review discusses current on injuries, focusing discoveries occurs, differences between types injury, time-course responses, key regulatory steps pyroptosis. addition, we highlight investigational agents are capable regulating discuss these may used therapies trauma.