Theory of the Effects of Concentration and Chain Length on Helix—Coil Equilibria in Two‐Stranded Nucleic Acids
作者： Jon Applequist , Vinayak Damle
DOI: 10.1063/1.1734089
关键词: Electromagnetic coil 、 Crystallography 、 Ultraviolet absorbance 、 Molecule 、 Formalism (philosophy of mathematics) 、 In degree 、 Chemistry 、 Nucleic acid 、 Chain length 、 Stereochemistry 、 Physical and Theoretical Chemistry 、 General Physics and Astronomy
摘要: The formalism for treating a dissociating two‐stranded helix is developed from the system partition function. behavior of finite chains examined according to model in which only one helical region allowed molecule, and staggering paired strands not allowed. Numerical results chain lengths range 1 300 residues show that helix—coil transition curve markedly broadened shifted as length decreases, decrease concentration significant degree bonding less than about 100. ultraviolet absorbance curves are calculated Rich—Tinoco predictions stack‐length dependence hypochromicity, found be different terms
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