Introduction: Immunosuppressants as Neuroprotective Agents

作者: Marcus F. Keep , Hiroyuki Uchino , Eskil Elmér

DOI: 10.1007/978-1-59259-315-6_1

关键词: Amyotrophic lateral sclerosisNeuroscienceNeurodegenerationIschemiaCyclosporin aTraumatic brain injuryOrgan transplantationNeurologyNeuroprotectionMedicine

摘要: The discovery that the two most powerful immunosuppressants, cyclosporin A and FK506, are also effective neuroprotectants known is profoundly important to neurology. Two drugs revolutionized field of organ transplantation as immunosuppressants beginning have an even greater impact on medicine in their new role neuroprotectants. elucidation mechanisms action these ischemia, trauma, neurodegeneration has enhanced our understanding some complexities neuronal death survival.

参考文章(88)
Willard E. Goodwin, Joseph J. Kaufman, Matlock M. Mims, Roderick D. Turner, Richard Glassock, Ralph Goldman, Morton M. Maxwell, Human Renal Transplantation. I, Clinical Experiences with Six Cases of Renal Homotransplantation The Journal of Urology. ,vol. 89, pp. 13- 24 ,(1963) , 10.1016/S0022-5347(17)64491-4
Cynthia L. Grosskreutz, Ellen E. Freeman, The effects of FK506 on retinal ganglion cells after optic nerve crush. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 1111- 1115 ,(2000)
John J. Lemasters, Anna-Liisa Nieminen, Ting Qian, Lawrence C. Trost, Brian Herman, The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury Molecular and Cellular Biochemistry. ,vol. 174, pp. 159- 165 ,(1997) , 10.1023/A:1006827601337
David M. Armistead, Methods and compositions for stimulating neurite growth Official Gazette of the United States Patent and Trademark Office Patents. ,(1996)
Jeffrey H. Kordower, Thomas B. Freeman, Er-Yun Chen, Elliott J. Mufson, Paul R. Sanberg, Robert A. Hauser, Barry Snow, C. Warren Olanow, Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease Movement Disorders. ,vol. 13, pp. 383- 393 ,(1998) , 10.1002/MDS.870130303
William G. Tatton, Ruth M. E. Chalmers-Redman, Mitochondria in neurodegenerative apoptosis: An opportunity for therapy? Annals of Neurology. ,vol. 44, ,(1998) , 10.1002/ANA.410440720
Steven P. Butcher, David C. Henshall, Yoshinori Teramura, Kazuhide Iwasaki, John Sharkey, Neuroprotective Actions of FK506 in Experimental Stroke: In Vivo Evidence against an Antiexcitotoxic Mechanism The Journal of Neuroscience. ,vol. 17, pp. 6939- 6946 ,(1997) , 10.1523/JNEUROSCI.17-18-06939.1997
Hermann G, Brittain Rs, Starzl Te, Marchioro Tl, Waddell Wr, Vonkaulla Kn, HOMOTRANSPLANTATION OF THE LIVER IN HUMANS. Surgery gynecology & obstetrics. ,vol. 117, pp. 659- 676 ,(1963)
Thomas E. Starzl, Personal Reflections in Transplantation Surgical Clinics of North America. ,vol. 58, pp. 879- 893 ,(1978) , 10.1016/S0039-6109(16)41629-4