Developmental Biology Related to Oncology
作者： Wolfgang Wechsler , Adalbert Koestner
DOI: 10.1007/978-1-4684-2301-3_6
关键词: Neoplastic transformation 、 Leukemia 、 Horizontal transmission 、 Transplacental 、 Genome 、 Biology 、 Ethylnitrosourea 、 Transmission (medicine) 、 Cancer research 、 Tumor Virus
摘要: Research in perinatal tumor induction experienced a new impetus past years through several important discoveries experimental chemical and viral oncogenesis. The following probably had the greatest impact: (1) proof that leukemia viruses can be transmitted rodents by infection from animal to animal, i.e., horizontal transmission, but also inheritance of genome generation generation, vertical transmission. (2) successful transplacental various organ tumors alkylating carcinogens (Mohr Althoff, 1964, 1965; Druckrey et al., 1966). (3) discovery high susceptibility rat fetuses oncogenic effect ethylnitrosourea (Ivankovic Druckrey, 1968).
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