Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization.
作者： Wichai Pornthanakasem , Darin Kongkasuriyachai , Chairat Uthaipibull , Yongyuth Yuthavong , Ubolsree Leartsakulpanich
关键词: Serine hydroxymethyltransferase 、 Biochemistry 、 Pyridoxal 、 Gene 、 Enzyme 、 Plasmodium falciparum 、 Isozyme 、 Biology 、 Mitochondrion 、 Pyrimidine metabolism
摘要: Background Serine hydroxymethyltransferase (SHMT), a pyridoxal phosphate-dependent enzyme, plays vital role in the de novo pyrimidine biosynthesis pathway malaria parasites. Two genes have been identified Plasmodium spp. encoding cytosolic SHMT (cSHMT) and putative mitochondria (mSHMT), but their roles not fully investigated.
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