Relationship between physical occupational exposures and health on semen quality: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study

摘要: Objective To study the relationship among occupation, health, and semen quality in a cohort of men attempting to conceive. Design Observational prospective cohort. Setting Not applicable. Patient(s) A total 501 couples discontinuing contraception were followed for 1 year while trying conceive; 473 (94%) provided one sample, 80% second sample. Intervention(s) None. Main Outcome Measure(s) Semen data obtained through at-home collection with next-day analysis/quantification. Result(s) In all, complete available 456 men, mean age 31.8 years. Work-related heavy exertion was consistently associated lower concentration sperm count. Thirteen percent who reported displayed oligospermia, compared 6% did not report workplace exertion. Shift work, night vibration, noise, heat, prolonged sitting quality. Men high blood pressure had significantly strict morphology scores normotensive (17% vs. 21%). contrast, hyperlipidemia, diabetes, composite comorbidities The number medications man taking as proxy health status There negative association between Conclusion(s) occupational exertion, hypertension, identified. As these are potentially modifiable factors, further research should determine whether treatment or cessation may improve male fecundity.