Normalization of Tumor Vasculature and Improvement of Radiation Response by Antiangiogenic Agents
作者： Erin Mendoza , Randy Burd , Phyllis Wachsberger , Adam P. Dicker
DOI: 10.1007/978-1-59745-184-0_18
关键词: Tumor vasculature 、 Radiation therapy 、 Cancer research 、 Antiangiogenic agents 、 Ionizing radiation 、 Angiogenesis 、 Medicine 、 Therapeutic index 、 Radiation response 、 Cancer
摘要: Recent preclinical studies have suggested that radiotherapy in combination with antiangiogenic/vasculature-targeting agents enhances the therapeutic ratio of ionizing radiation. Because is one most widely used treatments for cancer, it important to understand how best use these two modalities aid design rational patient protocols. The mechanisms interaction between and radiation are complex involve interactions tumor stroma vasculature cells themselves. These can decrease overall resistance by affecting both vasculature, thereby breaking codependent cycle growth angiogenesis. antiangiogenic/vascular targeting not fully understood, ideal way this potentially powerful cure has yet be determined. We described a number possible antiangiogenic
springer.com
sci-hub.st 参考文章(26)
Philippe Martinive, Bernard Gallez, Christine Baudelet, Pierre Sonveaux, Réginald Ansiaux, Nelson Beghein, Olivier Feron, Bénédicte F. Jordan, Vincent Grégoire, Julie De Wever, Thalidomide Radiosensitizes Tumors through Early Changes in the Tumor Microenvironment Clinical Cancer Research. ,vol. 11, pp. 743- 750 ,(2005)
Ruud P.M. Dings, Brent W. Williams, Chang W. Song, Arjan W. Griffioen, Kevin H. Mayo, Robert J. Griffin, Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells International Journal of Cancer. ,vol. 115, pp. 312- 319 ,(2005) , 10.1002/IJC.20850
Kirsten K Steinauer, Iris Gibbs, Shoucheng Ning, John N French, Jeff Armstrong, Susan J Knox, Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cells International Journal of Radiation Oncology Biology Physics. ,vol. 48, pp. 325- 328 ,(2000) , 10.1016/S0360-3016(00)00671-4
Ricky T. Tong, Yves Boucher, Sergey V. Kozin, Frank Winkler, Daniel J. Hicklin, Rakesh K. Jain, Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors Cancer Research. ,vol. 64, pp. 3731- 3736 ,(2004) , 10.1158/0008-5472.CAN-04-0074
Debabrata Saha, Hongryull Pyo, Hak Choy, COX-2 inhibitor as a radiation enhancer: new strategies for the treatment of lung cancer. American Journal of Clinical Oncology. ,vol. 26, pp. 70- 74 ,(2003) , 10.1097/01.COC.0000074161.92815.93
Carsten Nieder, Nicole Wiedenmann, Nicolaus Andratschke, Michael Molls, Current status of angiogenesis inhibitors combined with radiation therapy Cancer Treatment Reviews. ,vol. 32, pp. 348- 364 ,(2006) , 10.1016/J.CTRV.2006.03.006
Napoleone Ferrara, Hans-Peter Gerber, Jennifer LeCouter, None, The biology of VEGF and its receptors. Nature Medicine. ,vol. 9, pp. 669- 676 ,(2003) , 10.1038/NM0603-669
R. K. Jain, Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy Science. ,vol. 307, pp. 58- 62 ,(2005) , 10.1126/SCIENCE.1104819
Frank Winkler, Sergey V. Kozin, Ricky T. Tong, Sung-Suk Chae, Michael F. Booth, Igor Garkavtsev, Lei Xu, Daniel J. Hicklin, Dai Fukumura, Emmanuelle di Tomaso, Lance L. Munn, Rakesh K. Jain, Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. ,vol. 6, pp. 553- 563 ,(2004) , 10.1016/J.CCR.2004.10.011
Phyllis Wachsberger, Randy Burd, Adam P. Dicker, Improving tumor response to radiotherapy by targeting angiogenesis signaling pathways. Hematology-oncology Clinics of North America. ,vol. 18, pp. 1039- 1057 ,(2004) , 10.1016/J.HOC.2004.06.007