Schwannomas of the gastrointestinal tract: clinicopathological features of 12 cases including a case of esophageal tumor compared with those of gastrointestinal stromal tumors and leiomyomas of the gastrointestinal tract.

摘要: We analyzed the clinicopathological features of 12 gastrointestinal (GI) schwannomas and compared them with those 37 GI stromal tumors (GISTs) 15 leiomyomas. Grossly, showed rubbery to firm, yellow-white tan, glistening, often trabeculated cut surfaces, resembling soft tissue schwannomas. The GISTs were firm or fish-flesh gray-pink, variegated a degenerative change, leimyomas resembled typical uterine Histologically, moderately cellular focal significant nuclear pleomorphism rare mitotic figures. A characteristic peripheral lymphoid cuff was observed in all cases, but indistinct two cases. highly spindle cell, epithelioid or, occasionally, pleomorphic basophilic appearance. Leiomyomas paucicellular eosinophilic Immunohistochemically, S-100 protein- glial fibrillary acidic protein (GFAP)-positive, negative for c-kit, CD34, smooth muscle actin (SMA). c-kit- and/or CD34-positive, GFAP-negative. SMA-positive protein, GFAP. mean Ki-67 index schwannoma 0.7, GIST leiomyoma 5.9 0.3, respectively. patients leiomyomas had favorable outcome, whereas progression died disease. separation from is clinically important because former group has high risk malignant behavior. differed conventional that they cuffs, lacked fibrous capsule vascular hyalinization, rarely changes. schwannomas, however, many aspects, clinical, gross, histological, immunohistochemical different