Melanoma in 2013: Melanoma--the run of success continues.

作者: Dirk Schadendorf , Axel Hauschild

DOI: 10.1038/NRCLINONC.2013.246

关键词: DiseaseBlockadeInternal medicineImmunologyMEDLINEMedicineCutaneous melanomaMelanomaOncologyImmune checkpointCancer immunotherapy

摘要: In 2013, new insights on the molecular features of cutaneous melanoma provided a paradigm shift in our understanding biology this disease. Exploiting immune checkpoint blockade and use BRAF-targeted or MAPK-targeted agents contributed to important progress treatment management melanoma.

参考文章(9)
Alexander Roesch, Adina Vultur, Ivan Bogeski, Huan Wang, Katharina M Zimmermann, David Speicher, Christina Körbel, Matthias W Laschke, Phyllis A Gimotty, Stephan E Philipp, Elmar Krause, Sylvie Pätzold, Jessie Villanueva, Clemens Krepler, Mizuho Fukunaga-Kalabis, Markus Hoth, Boris C Bastian, Thomas Vogt, Meenhard Herlyn, None, Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells Cancer Cell. ,vol. 23, pp. 811- 825 ,(2013) , 10.1016/J.CCR.2013.05.003
S. Horn, A. Figl, P. S. Rachakonda, C. Fischer, A. Sucker, A. Gast, S. Kadel, I. Moll, E. Nagore, K. Hemminki, D. Schadendorf, R. Kumar, TERT Promoter Mutations in Familial and Sporadic Melanoma Science. ,vol. 339, pp. 959- 961 ,(2013) , 10.1126/SCIENCE.1230062
Antoni Ribas, F. Stephen Hodi, Margaret Callahan, Cyril Konto, Jedd Wolchok, Hepatotoxicity with Combination of Vemurafenib and Ipilimumab The New England Journal of Medicine. ,vol. 368, pp. 1365- 1366 ,(2013) , 10.1056/NEJMC1302338
Meghna Das Thakur, Fernando Salangsang, Allison S. Landman, William R. Sellers, Nancy K. Pryer, Mitchell P. Levesque, Reinhard Dummer, Martin McMahon, Darrin D. Stuart, Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance Nature. ,vol. 494, pp. 251- 255 ,(2013) , 10.1038/NATURE11814
Deborah A Knight, Shin Foong Ngiow, Ming Li, Tiffany Parmenter, Stephen Mok, Ashley Cass, Nicole M Haynes, Kathryn Kinross, Hideo Yagita, Richard C Koya, Thomas G Graeber, Antoni Ribas, Grant A McArthur, Mark J Smyth, None, Host immunity contributes to the anti-melanoma activity of BRAF inhibitors Journal of Clinical Investigation. ,vol. 123, pp. 1371- 1381 ,(2013) , 10.1172/JCI66236
Franklin W Huang, Eran Hodis, Mary Jue Xu, Gregory V Kryukov, Lynda Chin, Levi A Garraway, Highly Recurrent TERT Promoter Mutations in Human Melanoma Science. ,vol. 339, pp. 957- 959 ,(2013) , 10.1126/SCIENCE.1229259
Omid Hamid, Caroline Robert, Adil Daud, F. Stephen Hodi, Wen-Jen Hwu, Richard Kefford, Jedd D. Wolchok, Peter Hersey, Richard W. Joseph, Jeffrey S. Weber, Roxana Dronca, Tara C. Gangadhar, Amita Patnaik, Hassane Zarour, Anthony M. Joshua, Kevin Gergich, Jeroen Elassaiss-Schaap, Alain Algazi, Christine Mateus, Peter Boasberg, Paul C. Tumeh, Bartosz Chmielowski, Scot W. Ebbinghaus, Xiaoyun Nicole Li, S. Peter Kang, Antoni Ribas, Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma The New England Journal of Medicine. ,vol. 369, pp. 134- 144 ,(2013) , 10.1056/NEJMOA1305133
Jedd D. Wolchok, Harriet Kluger, Margaret K. Callahan, Michael A. Postow, Naiyer A. Rizvi, Alexander M. Lesokhin, Neil H. Segal, Charlotte E. Ariyan, Ruth-Ann Gordon, Kathleen Reed, Matthew M. Burke, Anne Caldwell, Stephanie A. Kronenberg, Blessing U. Agunwamba, Xiaoling Zhang, Israel Lowy, Hector David Inzunza, William Feely, Christine E. Horak, Quan Hong, Alan J. Korman, Jon M. Wigginton, Ashok Gupta, Mario Sznol, Nivolumab plus Ipilimumab in Advanced Melanoma The New England Journal of Medicine. ,vol. 369, pp. 122- 133 ,(2013) , 10.1056/NEJMOA1302369
Kerstin Trunzer, Anna C. Pavlick, Lynn Schuchter, Rene Gonzalez, Grant A. McArthur, Thomas E. Hutson, Stergios J. Moschos, Keith T. Flaherty, Kevin B. Kim, Jeffrey S. Weber, Peter Hersey, Georgina V. Long, Donald Lawrence, Patrick A. Ott, Ravi K. Amaravadi, Karl D. Lewis, Igor Puzanov, Roger S. Lo, Astrid Koehler, Mark Kockx, Olivia Spleiss, Annette Schell-Steven, Houston N. Gilbert, Louise Cockey, Gideon Bollag, Richard J. Lee, Andrew K. Joe, Jeffrey A. Sosman, Antoni Ribas, Pharmacodynamic Effects and Mechanisms of Resistance to Vemurafenib in Patients With Metastatic Melanoma Journal of Clinical Oncology. ,vol. 31, pp. 1767- 1774 ,(2013) , 10.1200/JCO.2012.44.7888