作者: Dirk Schadendorf , Axel Hauschild
DOI: 10.1038/NRCLINONC.2013.246
关键词: Disease 、 Blockade 、 Internal medicine 、 Immunology 、 MEDLINE 、 Medicine 、 Cutaneous melanoma 、 Melanoma 、 Oncology 、 Immune checkpoint 、 Cancer immunotherapy
摘要: In 2013, new insights on the molecular features of cutaneous melanoma provided a paradigm shift in our understanding biology this disease. Exploiting immune checkpoint blockade and use BRAF-targeted or MAPK-targeted agents contributed to important progress treatment management melanoma.