Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads
作者： Shanta Dhar , Weston L. Daniel , David A. Giljohann , Chad A. Mirkin , Stephen J. Lippard
DOI: 10.1021/JA9071282
关键词: Cisplatin 、 Combinatorial chemistry 、 Platinum 、 Prodrug 、 Stereochemistry 、 Chemistry 、 Adduct 、 Colloidal gold 、 Conjugate 、 Cytotoxicity 、 Drug carrier
摘要: Polyvalent oligonucleotide gold nanoparticle conjugates (DNA-AuNPs) have appealing properties for drug delivery applications, including high cellular uptake in a variety of cell types, no demonstrated toxicity inherent to the conjugate, and resistance to enzymatic degradation. In this chapter, the authors have combined the properties of DNA-AuNPs and platinum (IV) prodrugs into a single agent for drug delivery. DNA-AuNPs were synthesized, characterized, and tested in vitro as carriers for Pt (IV) prodrugs. The conjugate was …
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