The ADAMs: New Therapeutic Targets for Cancer?

摘要: The ADAMs are transmembrane proteins implicated in a variety of biological processes including proteolysis, cell signalling, angiogenesis, migration, and adhesion. Of the 21 believed to be functional humans, approximately one half have been shown possess protease activity. As proteases, main ADAM substrates ectodomains proteins, especially growth factor precursors, receptors, adhesion proteins. Recently, several different play role cancer formation progression. These include ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM28. Consistent with causative cancer, ADAMs, 10 17, emerging as potential therapeutic targets for treatment. Indeed, targeting these either low molecular weight inhibitors or monoclonal antibodies has anticancer activity multiple preclinical systems. Although early phase clinical trials no serious side effects dual ADAM10/17 inhibitor, consequences long-term treatment agents unknown.