Density fluctuations in saturated phospholipid bilayers increase as the acyl-chain length decreases

作者: J.H. Ipsen , K. Jørgensen , O.G. Mouritsen

DOI: 10.1016/S0006-3495(90)82452-8

关键词: BilayerCompressibilityThermodynamicsLipid bilayerSynthetic membranePhase transitionPhospholipidChromatographyIon transporterChemistryPhosphatidylcholine

摘要: A systematic computer simulation study is conducted for a model of the main phase transition fully hydrated saturated diacyl phosphatidylcholine bilayers (DMPC, DPPC, and DSPC). With particular focus on fluctuation effects thermal properties in region, yields data specific heat, lateral compressibility, lipid-domain size distribution. Via simple assumption transmembrane passive ion permeability derived from interfacial measure. comparative analysis various shows, agreement with number experiments, that density fluctuations hence response functions increase as acyl-chain length decreased.

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