Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics.

摘要: The presence of quiescent cell populations in solid tumors represents a major challenge for disease eradication. Such cells are generally present poorly vascularized tumor areas, show limited sensitivity to traditional chemotherapeutical drugs, and tend resume proliferation, resulting reseeding growth. There is growing recognition the importance developing therapies that target these achieve long-lasting remission. Recent studies have shown combination hypoxia reduced nutrient availability areas results metabolic plasticity coupled with an increased perturbations mitochondrial flux. Targeting bioenergetics may enable eradication improve prognosis patients cancer.