Left-handed double helical DNA: variations in the backbone conformation

作者: A. Wang , G. Quigley , F. Kolpak , G van der Marel , J. van Boom

DOI: 10.1126/SCIENCE.7444458

关键词: Torsion (mechanics)Crystal structurePhosphateDiffractionDNAZ-DNAMoleculeMagnesium ionCrystallographyChemistry

摘要: Four different crystals of d(CpGpCpGpCpG) have been solved by x-ray diffraction analysis and all form similar left-handed double helical Z-DNA molecules in the crystal lattice. Two conformations are observed for phosphates GpC sequences, as found either facing groove or rotated away from it. The latter conformation is often when hydrated magnesium ions complexed to a phosphate oxygen atom. These may be used right-handed B-DNA joins Z-DNA. Atomic coordinates torsion angles presented both types

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