Experimental infection with chamois border disease virus causes long-lasting viraemia and disease in Pyrenean chamois (Rupicapra pyrenaica).

摘要: Since 2001, severe outbreaks of disease associated with border virus (BDV) infection have been reported in Pyrenean chamois. The is characterized by variable degrees cachexia, alopecia and neurological manifestations prior to death. aim this study was investigate under experimental conditions. To assess viral virulence, humoral immune response, dissemination probable routes transmission, seven chamois (five seronegative two seropositive for BDV) were inoculated a BDV isolated from naturally infected A group three maintained as uninfected controls. five became viraemic day 2 post-inoculation (p.i.) until their death (three animals) or the end experiment (on 34 p.i.) developed neutralizing antibodies 18 p.i. study. Continuous shedding detected RT-PCR oral, nasal rectal swabs 5 Despite none showing obvious signs, all them had non-suppurative meningoencephalitis seen BDV-seropositive did not become viraemic. This confirms that primary agent has affecting populations recent years Pyrenees previously acquired immunity protective.