Inhibition of the biosynthesis of 5-hydroxytryptamine in rat brain by imipramine
作者： J. Bruinvels
DOI: 10.1016/0014-2999(72)90153-7
关键词: Serotonin 、 Endocrinology 、 Imipramine 、 Internal medicine 、 Pharmacology 、 Tryptophan 、 Serotonin Antagonists 、 Chemistry 、 In vitro 、 Probenecid 、 Biosynthesis 、 Rat brain
摘要: Abstract Administration of imipramine, 30 mg/kg, i.p., to rats decreased 5-HIAA and increased 5-HT in the brain. The increase brain was inconsistent. Imipramine inhibited accumulation rat after pretreatment with probenecid. 1-tryptophan (1-TP) imipramine-pretreated resulted an which significantly lower than controls. When 1-5-hydroxytryptophan given instead 1-TP, formation not but showed a tendency be increased. After administration rise plasma TP higher imipramine pretreated Uptake 1-TP by crude synaptosomal fraction vitro that uptake competitively. It is concluded might inhibit biosynthesis inhibiting TP.
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