Wheat bran affects the site of fermentation of resistant starch and luminal indexes related to colon cancer risk: a study in pigs

摘要: BACKGROUND Recent studies suggest that resistant starch (effective in producing butyrate and lowering possibly toxic ammonia) is rapidly fermented the proximal colon; distal colon especially would, however, benefit from these properties of starch. AIMS To determine whether wheat bran (a rich source insoluble non-starch polysaccharides), known to hasten gastrointestinal transit, could carry through thus shift its site fermentation. METHODS Twenty four pigs were fed human type diets: a control diet, or diet supplemented with starch, bran, both. Intestinal contents faeces collected after two weeks. RESULTS Without was caecum colon. Supplementation inhibited caecal fermentation resulting an almost twofold increase (from 12.9 (2.5) 20.5 (2.1) g/day, p CONCLUSIONS Wheat can further distally, thereby improving luminal conditions colonic regions where tumours most commonly occur. Therefore, combined consumption polysaccharides may contribute dietary modulation cancer risk.