Autoantibodies against cytoplasmic structures of neutrophil granulocytes in Wegener's granulomatosis.

摘要: Autoantibodies against cytoplasmic components of neutrophil granulocytes (ACPA) were detected in 18 32 patients with Wegener's granulomatosis (WG), but none the controls (n = 900), including glomerulonephritis, sarcoidosis, tuberculosis, polyarteritis nodosa, and connective tissue diseases, healthy blood donors. The presence and, to a lesser extent, titre ACPA correlated severity activity disease. could be only three 11 limited form disease complete remission. In contrast, all active extensive disease, present higher titre, most partial remission (eight 12) antibodies demonstrable, especially those frequent relapses. Furthermore, antibody significantly C-reactive protein concentration (P less than 0.05), other laboratory parameters. conclusion, have proven highly specific marker great clinical significance that provides us useful tool confirm, or even establish. diagnosis WG.