Comparison of plasma pharmacokinetics and bioavailability of ceftiofur sodium and ceftiofur hydrochloride in pigs after a single intramuscular injection

摘要: Ceftiofur sodium, a broad-spectrum cephalosporin, is active against gram-positive and gram-negative pathogens of veterinary importance. Two studies were designed to compare the intramuscular bioavailability current sodium salt new hydrochloride in pigs at doses either 3 mg or 5 ceftiofur equivalents (CE)/kg body weight. Twenty-six healthy young selected for these two-period, two-treatment crossover studies, 12 mg/kg study 14 study. Each animal received one (i.m.) injection i.m. with 14-day washout period between two treatments. Blood samples collected serially up 96 h postinjection. Plasma then analysed using validated assay that measures all desfuroylceftiofur-related metabolites by high-performance liquid chromatography. In dosage study, average maximum plasma concentration (C(max)) after administration was 15.8+/-3.40 microg/mL 0.4-4 injection. After hydrochloride, C(max) 11.8+/-1.67 1-4 Concentrations 72 0.392+/-0.162 0.270+/-0.118 sodium. The mean area under curve (AUC), from time 0 limit quantitation (AUC(O-LOQ)) administration, 216+/-28.0 microg x h/mL, compared 169+/-45.4 h/mL administration. calculated during which concentrations remained above 0.02 (t(>0.2)) 85.3+/-10.6 77.2+/-10.7 hydrochloride. 28.3+/-4.45 0.33-2 29.7+/-6.72 0.66-2 0.274+/-0.0550 0.224+/-0.0350 AUC(O-LOQ) 382+/-89.8 302+/-54.4 t(>0.2) 78.9+/-9.65 94.2+/-8.64 Based on similarity pharmacokinetic parameters formulations ceftiofur, similar therapeutic efficacy can be inferred products.