Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats.
作者： Rupesh Shirodkar , Chandrasekhar Misra , Chethan GH , Pallavi Shetty , Zenab Attari
DOI: 10.1155/2015/947623
关键词: Liver weight 、 Medicine 、 Physiology 、 Toxicity 、 Normal range 、 Pharmacology 、 Body weight 、 Subacute toxicity 、 Granulocyte count 、 Male rats 、 Lacidipine
摘要: The present study was aimed at investigating the safety of Lacidipine (LCDP) loaded nanostructured lipid carriers (NLCs) in Wistar rats. NLCs were formulated using ultrasound dispersion technique. Animals orally treated once daily with containing 0.140 mg, 0.350 mg, and 0.875 mg LCDP as low, medium, high dose per kg body weight, respectively, during 28 days along blank formulation pure LCDP. Control rats fed water. observed throughout experiment period their weight recorded weekly. Overnight fasted sacrificed on 29th day. Study revealed no signs or symptoms toxicity morbidity. No significant changes between control group. Significant increase left testis liver male female rats, respectively. Haematological estimation decrease haemoglobin count while showed granulocyte count. All serum clinical parameters within normal range gross histopathological observed. delayed effect noted satellite results indicate that developed are safe when administered
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