Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer
作者： Fei Mao , Zongyuan Xu , Shuo Gu , Xiaobing Niu
DOI: 10.1039/C8RA08083F
关键词: Cancer research 、 Biology 、 PCA3 、 Glycolysis 、 Kinase 、 Prostate cancer 、 Competing endogenous RNA 、 Gene knockdown 、 Long non-coding RNA 、 Anaerobic glycolysis
摘要: Prostate cancer is one of the common tumor malignancies in men worldwide. Although long noncoding RNAs (lncRNAs) have been demonstrated to play essential roles progression prostate cancer, and potential mechanism lncRNA antigen 3 (PCA3) remain poorly understood. In present study, we investigated role PCA3 aerobic glycolysis, viability apoptosis cells probed interaction between microRNA-1 (miR-1)/cyclin-dependent kinase 4 (CDK4). Here found that CDK4 were up-regulated while miR-1 was down-regulated tissues cells. Moreover, knockdown inhibited glycolysis induced Intriguingly, bound inhibition reversed regulatory effect on Besides, indicated as a target it regulated by through functioning competing endogenous RNA (ceRNA) The results might drive regulating miR-1/CDK4 axis cells, providing promising avenue for treatment cancer.
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