Improved language performance in Alzheimer disease following brain stimulation

摘要: Objectives Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible treatment for the cognitive deficits associated with Alzheimer disease (AD). The aim of this study was to assess long-term effects, on performance, rTMS applied left dorsolateral prefrontal cortex (DLPFC) in AD patients. Methods Ten patients were randomly assigned one two groups. Multiple-baseline design used.The first group underwent 4-week real protocol, while second 2-week placebo treatment, followed by 2 weeks stimulation. Each session consisted application rhythmic high-frequency over DLPFC 25 min. Sessions occurred once daily, 5 days/ week. main analysed outcome change test performance at and 4 after initiation, follow-up performed 8 end rTMS, comparison baseline performance. Results A significant difference found between groups sessions terms percentage correct responses auditory sentence comprehension. Only induced an improvement respect or placebo. Moreover, both showed lasting effect improved treatment. Conclusion findings provide initial evidence persistent beneficial effects comprehension Rhythmic conjunction other therapeutic interventions, may represent novel approach language dysfunction