An Algorithm for the Operational Assessment of Adverse Drug Reactions

摘要: Despite widespread clinical and epidemiologic attention to adverse drug reactions (ADRs), their identification has been a nonreproducible act of unspecified subjective judgment; adequate operational criteria have not available for diagnostic decisions about the cause an observed untoward manifestation. To improve scientific precision in diagnosis ADRs, we developed algorithm that provides detailed ranking probability causation when ADR is suspected between The scoring system six axes decision strategy: previous general experience with drug, alternative etiologic candidates, timing events, levels evidence overdose, dechallenge, rechallenge. sum scores ordinally partitioned rate candidate as definite, probable, possible, or unlikely. (JAMA242:623-632, 1979)