Nitric Oxide Transport in Blood: A Third Gas in the Respiratory Cycle

摘要: The trapping, processing, and delivery of nitric oxide (NO) bioactivity by red blood cells (RBCs) have emerged as a conserved mechanism through which regional flow is linked to biochemical cues perfusion sufficiency. We present here an expanded paradigm for the human respiratory cycle based on coordinated transport three gases: NO, O₂, CO₂. By linking O₂ NO flux, RBCs couple vessel caliber (and thus flow) availability in lung need periphery. elements required regulated O₂-based signal transduction via controlled processing within are presented herein, including S-nitrosothiol (SNO) synthesis hemoglobin O₂-regulated (capture, activation, groups at sites remote from synthase). role molecular, microcirculatory, system levels reviewed. elucidate supports homeostasis, not only adaptive regulation systemic but also optimizing ventilation-perfusion matching lung. Furthermore, we discuss central control breathing baroreceptor pressure, subserve supply tissue. Additionally, malfunctions this signaling that implicated wide array pathophysiologies described. Understanding (dys)function prerequisite development novel therapies target vasoactive capacities RBCs.