CD30-CD30 ligand interaction in primary cutaneous CD30(+) T-cell lymphomas: A clue to the pathophysiology of clinical regression.

摘要: Primary CD30(+) cutaneous T-cell lymphomas (CTCLs) represent a spectrum of non-Hodgkin's (NHLs) that have been well defined at the clinical, histologic, and immunologic level. This group, which includes 2 main entities (large cell lymphoma lymphomatoid papulosis [LyP]) borderline cases, is characterized by expression CD30 antigen neoplastic large cells presentation, possible spontaneous regression skin lesions, generally favorable clinical course. Although functional relevance its natural ligand (CD30L) in most cases NHL presently undefined, previous studies indicate CD30L likely to mediate reduction proliferation anaplastic large-cell NHL. No information currently available concerning primary CTCLs. In this study, we investigated immunophenotypic genotypic different developmental phases lesions (growing v spontaneously regressing). By immunohistochemistry, was detected regressing only; molecular analysis, clearly higher than growing ones. CD30L, while expressed some small lymphocytes, often coexpressed cells, as demonstrated 2-color immunofluorescence immunohistochemistry on paraffin sections. Taken together, these data suggest CD30-CD30L interaction may play role pathobiology lymphoproliferative disorders. particular, (over)expression might major mechanism self-regression distinctive feature subtype.