Dietary caffeine intake does not affect methotrexate efficacy in patients with rheumatoid arthritis.

摘要: OBJECTIVE: Methylxanthines, like caffeine, have been thought to reverse the antiinflammatory effects of methotrexate (MTX) in rheumatoid arthritis (RA). We investigated whether patients with RA taking MTX a higher dietary caffeine intake worse clinical response than those lower intake. METHODS: Patients enrolled prospective cohort study and currently were divided equally into low, moderate, high consumers. was defined by Disease Activity Score (DAS)28, Multidimensional Health Assessment Questionnaire (MDHAQ) score, duration morning stiffness. Regression models used relationship between adjusting for age, sex, other relevant variables at enrollment. RESULTS: Two hundred sixty-four had an average 211.7 mg dose 16.0 mg/wk. The low group comprised 87 patients, moderate 86, 91. In 3 multivariate models, there no statistical difference efficacy groups, as measured DAS28 MDHAQ stiffness Moderate scores, physician9s global assessment, swollen joint counts, but differences not significant. CONCLUSION: Caffeine among doses did affect disease activity over time.