Inhibition of monoamine oxidase isoforms modulates nicotine withdrawal syndrome in the rat

摘要: Abstract Aims There have been many reports of monoamine oxidase (MAO) inhibition by non-nicotine ingredients in tobacco smoke, persisting for days after smoking cessation. This study determined the effect inhibiting MAO and its isoforms on nicotine withdrawal syndrome. Main methods Rats were rendered nicotine-dependent seven subcutaneous (s.c.) 9 mg/kg/day infusion bitartrate. Twenty-two hours termination infusion, they observed over 20 min somatically expressed signs. Three before observation, rats injected intraperitoneally (i.p.) with 4 mg/kg each A antagonist clorgyline B deprenyl, or saline alone. similar experiment was performed non-dependent, saline-infused rats. Another compared that received injections either further receiving deprenyl Key findings Combined treatment both inhibitors markedly significantly exacerbated signs infused rats, while having no significant effects s.c. alone had more than saline-injected deprenyl-injected fewer controls. Assays confirmed thoroughly reduced enzymatic activity activity. Significance The results suggest may contribute to intensity syndrome