Sildenafil improves cardiac output and exercise performance during acute hypoxia, but not normoxia.

作者: Andrew R. Hsu , Kimberly E. Barnholt , Nicolas K. Grundmann , Joseph H. Lin , Stewart W. McCallum

DOI: 10.1152/JAPPLPHYSIOL.00806.2005

关键词: Exercise performanceCardiologyPhysical exerciseRespiratory diseasePulmonary hypertensionPhosphodiesterase 5 inhibitorCardiac outputHypoxia (medical)SildenafilEndocrinologyInternal medicineMedicine

摘要: Sildenafil causes pulmonary vasodilation, thus potentially reducing impairments of hypoxia-induced hypertension on exercise performance at altitude. The purpose this study was to deter...

参考文章(48)
Thomas Hornbein, Robert Schoene, High Altitude : An Exploration of Human Adaptation CRC Press. ,(2001) , 10.3109/9780203908044
S H Francis, J D Corbin, Pharmacology of phosphodiesterase-5 inhibitors. International Journal of Clinical Practice. ,vol. 56, pp. 453- 459 ,(2002)
P. D. Wagner, J. R. Sutton, J. T. Reeves, A. Cymerman, B. M. Groves, M. K. Malconian, Operation Everest II: pulmonary gas exchange during a simulated ascent of Mt. Everest Journal of Applied Physiology. ,vol. 63, pp. 2348- 2359 ,(1987) , 10.1152/JAPPL.1987.63.6.2348
Victor Dishy, Paul A. Harris, Rosanna Pierce, Harish C. Prasad, Gbenga Sofowora, Holly L. Bonar, Alastair J. J. Wood, C. Michael Stein, Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers British Journal of Clinical Pharmacology. ,vol. 57, pp. 209- 212 ,(2003) , 10.1046/J.1365-2125.2003.01974.X
K.-K. TEO, M. D HETHERINGTON, R. G HAENNEL, P. V GREENWOOD, R. E ROSSALL, T. KAPPAGODA, Cardiac output measured by impedance cardiography during maximal exercise tests. Cardiovascular Research. ,vol. 19, pp. 737- 743 ,(1985) , 10.1093/CVR/19.12.737
Graham Jackson, Nigel Benjamin, Neville Jackson, Michael J Allen, Effects of sildenafil citrate on human hemodynamics The American Journal of Cardiology. ,vol. 83, pp. 13- 20 ,(1999) , 10.1016/S0002-9149(99)00043-0
Antoni Ricart, Jaume Maristany, Núria Fort, Conxita Leal, Teresa Pagés, Ginés Viscor, Effects of Sildenafil on the Human Response to Acute Hypoxia and Exercise High Altitude Medicine & Biology. ,vol. 6, pp. 43- 49 ,(2005) , 10.1089/HAM.2005.6.43
A Mahmud, M Hennessy, J Feely, Effect of sildenafil on blood pressure and arterial wave reflection in treated hypertensive men. Journal of Human Hypertension. ,vol. 15, pp. 707- 713 ,(2001) , 10.1038/SJ.JHH.1001244
Hossein A. Ghofrani, Frank Reichenberger, Markus G. Kohstall, Eike H. Mrosek, Timon Seeger, Horst Olschewski, Werner Seeger, Friedrich Grimminger, Sildenafil Increased Exercise Capacity during Hypoxia at Low Altitudes and at Mount Everest Base Camp Annals of Internal Medicine. ,vol. 141, pp. 169- 177 ,(2004) , 10.7326/0003-4819-141-3-200408030-00005