Comparative Analysis of Gender-Related Differences in Symptoms and Referral Patterns prior to Initial Diagnosis of Urothelial Carcinoma of the Bladder: A Prospective Cohort Study

作者: Atiqullah Aziz , Stephan Madersbacher , Wolfgang Otto , Roman Mayr , Evi Comploj

DOI: 10.1159/000363334

关键词: Internal medicineUrothelial carcinomaCarcinomaGynecologyDysuriaUrinary systemReferralSex characteristicsProspective cohort studyMedicineCystoscopy

摘要: Objective: To analyze gender-specific differences regarding clinical symptoms, referral patterns and tumor biology prior to initial diagnosis of urothelial carcinoma the bladder (UCB). Methods: A consecutive series patients with an UCB was included. All completed a questionnaire on demographics, symptoms patterns. Results: In total, 68 (50 men, 18 women) newly diagnosed at admission for transurethral resection tumors were recruited. Dysuria more often observed in women (55.6 vs. 38.0%, p = 0.001). Direct consultation urologist conducted by 84.0% males 66.7% females (p 0.120). One third saw their general practitioner and/or gynecologist once or twice 0.120) before urologist. Furthermore, significantly treated urinary tract infections than men (61.1 20.0%, 0.005). Cystoscopy first presentation performed (88.0 66.7%, 0.068), favorable detection rate cystoscopy (96.0 50.0%, Conclusions: Delayed might lead deferred consequently adverse outcome. Thus, primary care physicians consider referring complaints specialized earlier.

参考文章(28)
Armin Henning, Marlies Wehrberger, Stephan Madersbacher, Armin Pycha, Thomas Martini, Evi Comploj, Klaus Jeschke, Christian Tripolt, Michael Rauchenwald, Do differences in clinical symptoms and referral patterns contribute to the gender gap in bladder cancer? BJU International. ,vol. 112, pp. 68- 73 ,(2013) , 10.1111/J.1464-410X.2012.11661.X
Bastian Keck, Oliver J. Ott, Lothar Häberle, Frank Kunath, Christian Weiss, Claus Rödel, Rolf Sauer, Rainer Fietkau, Bernd Wullich, Frens S. Krause, Female sex is an independent risk factor for reduced overall survival in bladder cancer patients treated by transurethral resection and radio- or radiochemotherapy World Journal of Urology. ,vol. 31, pp. 1023- 1028 ,(2013) , 10.1007/S00345-012-0971-5
Marcus Horstmann, Ralf Witthuhn, Markus Falk, Arnulf Stenzl, Gender-specific differences in bladder cancer: a retrospective analysis. Gender Medicine. ,vol. 5, pp. 385- 394 ,(2008) , 10.1016/J.GENM.2008.11.002
Edward M. Messing, Theresa B. Young, Vernon B. Hunt, Jennifer M. Wehbie, Paul Rust, Urinary tract cancers found by homescreening with hematuria dipsticks in healthy men over 50 years of age Cancer. ,vol. 64, pp. 2361- 2367 ,(1989) , 10.1002/1097-0142(19891201)64:11<2361::AID-CNCR2820641128>3.0.CO;2-4
Opeyemi Adegboyega Falebita, Garry Lee, Paul Sweeney, Urine Cytology in the Evaluation of Urological Malignancy Revisited: Is It Still Necessary? Urologia Internationalis. ,vol. 84, pp. 45- 49 ,(2010) , 10.1159/000273465
Wolfgang Otto, Matthias May, Hans-Martin Fritsche, Duska Dragun, Atiqullah Aziz, Michael Gierth, Lutz Trojan, Edwin Herrmann, Rudolf Moritz, Jörg Ellinger, Derya Tilki, Alexander Buchner, Thomas Höfner, Sabine Brookman-May, Philipp Nuhn, Christian Gilfrich, Jan Roigas, Mario Zacharias, Stefan Denzinger, Markus Hohenfellner, Axel Haferkamp, Stefan C. Müller, Arkadius Kocot, Hubertus Riedmiller, Wolf F. Wieland, Christian G. Stief, Patrick J. Bastian, Maximilian Burger, Analysis of sex differences in cancer-specific survival and perioperative mortality following radical cystectomy: results of a large German multicenter study of nearly 2500 patients with urothelial carcinoma of the bladder. Gender Medicine. ,vol. 9, pp. 481- 489 ,(2012) , 10.1016/J.GENM.2012.11.001
J.L. Gutiérrez Baños, M.H. Rebollo Rodrigo, F.M. Antolín Juárez, B. Martín García, NMP 22, BTA stat test and cytology in the diagnosis of bladder cancer: a comparative study. Urologia Internationalis. ,vol. 66, pp. 185- 190 ,(2001) , 10.1159/000056612
Faysal A. Yafi, Armen G. Aprikian, Simon Tanguay, Wassim Kassouf, Patients with microscopic and gross hematuria: practice and referral patterns among primary care physicians in a universal health care system. Cuaj-canadian Urological Association Journal. ,vol. 5, pp. 97- 101 ,(2011) , 10.5489/CUAJ.10059
Richard J. Sylvester, Adrian P.M. van der Meijden, Willem Oosterlinck, J. Alfred Witjes, Christian Bouffioux, Louis Denis, Donald W.W. Newling, Karlheinz Kurth, Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. European Urology. ,vol. 49, pp. 466- 477 ,(2006) , 10.1016/J.EURURO.2005.12.031
Luis A. Kluth, Harun Fajkovic, Evanguelos Xylinas, Joseph J. Crivelli, Niccolo Passoni, Morgan Rouprêt, Andreas Becker, Evi Comploj, Armin Pycha, Sten Holmang, Amit Gupta, Yair Lotan, Pierre I. Karakiewicz, Paolo Gontero, Felix K.-H. Chun, Margit Fisch, Douglas S. Scherr, Shahrokh F. Shariat, Female gender is associated with higher risk of disease recurrence in patients with primary T1 high-grade urothelial carcinoma of the bladder World Journal of Urology. ,vol. 31, pp. 1029- 1036 ,(2013) , 10.1007/S00345-012-0996-9