Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals.

摘要: Abstract Background and aim Fibroblast growth factor 21 (FGF21) is positively associated with body mass index, potentially as a compensatory mechanism to mediate obesity related metabolic inflammatory insult due chronic low-grade elevations of the pro-inflammatory cytokines interleukin-6 (IL-6) tumor necrosis alpha (TNF-α). Therefore, FGF21 response in obese subjects associations increased cytokines, insulin resistance, energy utilization warrants investigation. Methods results Twenty four untrained (12 12 normal-weight) performed 30 min continuous submaximal aerobic exercise. Following exercise, exhibited blunted exercise compared normal-weight indicated by area-under-the-curves "with respect increase" (AUCi) analyses ( p  = 0.005). Furthermore, while exercise-induced plasma was not any cytokine (IL-6 TNF-α) response, AUCi correlated glucose (r = 0.495,  = 0.014), total relative expenditure (r = 0.562,  = 0.004), maximal oxygen consumption (VO 2max ; r = 0.646,  = 0.001) all subjects. Conclusion Impaired cardiorespiratory fitness may influence sensitivity acute individuals, contributing attenuated (e.g., glucose) expenditure. training aimed at improving and/or composition augment cardioprotective properties against obesity-associated CVD through enhanced flux.