From Humans to Dogs and Back: The Translational Lesson of Metronomic Chemotherapy

摘要: The main priority in veterinary oncology is to maintain patient quality of life. It important that new chemotherapy strategies aim minimize side effects, thus making the treatment attractive for owners as well their pets. Metronomic has been shown have an stabilizing effect on human cancer (including chemotherapy-resistant disease) resulting prolonged clinical benefit. In addition, this form positive effects life patients with various types cancer. These are obtained without any indication high grade toxicity. Moreover, low cost and oral administration (which reduces need hospitalization enables stay at home longer) key characteristics schedule, offering advantages frail subgroups (e.g., old patients) whom therapeutic options greatly needed. From another perspective, use metronomic dogs could reveal innovative schedules be applied humans. Veterinary cases treated represent unique opportunity ethically investigate novel drugs or combination treatments may highly translatable community. present review was describe how evolved canine far.