Chiral Amine Enantiomeric Excess Determination Using Self-Assembled Octahedral Fe(II)-Imine Complexes
作者： Justin M. Dragna , Alexandra M. Gade , Lee Tran , Vince M. Lynch , Eric V. Anslyn
DOI: 10.1002/CHIR.22426
关键词: Diimine 、 Ultraviolet visible spectroscopy 、 Photochemistry 、 Polymer chemistry 、 Imine 、 Amine gas treating 、 Chemistry 、 Schiff base 、 Trifluoromethanesulfonate 、 Circular dichroism 、 Enantiomeric excess 、 Organic chemistry 、 Analytical chemistry 、 Spectroscopy 、 Pharmacology 、 Drug discovery 、 Catalysis
摘要: A receptor assembly composed of iron(II) triflate and pyridine-2,6-dicarbaldehyde is used to determine the enantiomeric excess alpha-chiral primary amines using circular dichroism spectroscopy. The alpha chiral condense with dialdehyde form a diimine, which forms 2:1 octahedral complex iron(II). values unknown concentrations were determined by constructing calibration curves for each amine then measuring ellipticity at 600nm. This improves our previously reported assay determination further increasing wavelength CD measured reducing absolute error assay.
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