作者: R. Lawrenson , J.-C. Todd , G. M. Leydon , T. J. Williams , R. D. T. Farmer
DOI: 10.1046/J.1365-2125.2000.00199.X
关键词: Pulmonary embolism 、 Venous thromboembolism 、 Database 、 Thrombosis 、 General practice 、 Deep vein 、 Case-control study 、 Medicine 、 Epidemiology 、 Death certificate
摘要: Aims The study was conducted to determine whether the method for selecting cases of venous thromboembolism (VTE) from general practice databases significantly affected findings an epidemiological study. Methods Cases VTE were identified UK General Practice Research Database (GPRD) by searching codes deep vein thrombosis (DVT) and pulmonary embolism (PE). These had be supported evidence anticoagulation exposed a combined oral contraceptive (COC) at time event. Additional information about event sought practitioners who requested complete questionnaire supply anonymised copies hospital letters discharge summaries. Results Of 285 GPRD, additional available 177 events. This showed that 84% those events investigations or death certificate. Using only verified cases, rather than all GPRD events, did not alter results study. Conclusions provides sufficiently high quality allow valid research Excluding without database record admission would lead being overlooked, under-estimate disease incidence.