Autoantibodies to components of the mitotic apparatus.
作者： Jerome B Rattner , Gary J Mack , Marvin J Fritzler , None
关键词: Immunology 、 Centrosome 、 Sclerodactyly 、 Autoantibody 、 Cell cycle 、 Spindle apparatus 、 Primary biliary cirrhosis 、 IIf 、 Cancer research 、 Biology 、 Microtubule-associated protein
摘要: Autoantibodies directed to a variety of cellular antigens and organelles are feature autoimmune diseases. They have proven useful in clinical setting establish diagnosis, estimate prognosis, follow disease progression, alter therapy, initiate new investigations. Cellular molecular biologists used autoantibodies as probes identify molecules involved key processes. One the most interesting sets those that target within mitotic apparatus (MA). The MA includes chromosomes, spindle microtubules centrosomes. identification, localization, function, relevance autoantigens is focus this review. Abbreviations: ATP – adenosine triphosphate; CENP centromere protein; CREST calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia; HMG high mobility group; IB intercellular bridge; IIF indirect immunofluorescence; MAPs microtubule associated proteins; NuMA nuclear apparatus; NOR nucleolar organizer; PBC primary biliary cirrhosis; PM polymyositis; Pol I, II, III RNA polymerases; RA-rheumatoid arthritis; SLE systemic lupus erythematosus; SS Sjogren's syndrome; SSc sclerosis; topo topoisomerase.
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