In vivo assessment of the human sperm acrosome reaction and the expression of glycodelin-A in human endometrium after levonorgestrel-emergency contraceptive pill administration

作者: Josiane A.A. do Nascimento , Markku Seppala , Antero Perdigão , Ximena Espejo-Arce , Maria José Munuce

DOI: 10.1093/HUMREP/DEM119

关键词: BiologyAndrologyInternal medicineAcrosome reactionSemenLevonorgestrelPopulationEndocrinologyUterusEndometriumSpermIn uteroObstetrics and gynaecologyRehabilitationReproductive medicine

摘要: sies. RESULTS: Twenty-four and forty-eight hours after treatment, there were 14.5+ 3.9 3 10 6 17.3+ 6.8 sperm recovered from the uterus, respectively. There no differences between AR rate endometrial glycodelin-A staining intensity in an LNG or placebo treated cycles. The uterine flushing medium represented 1.38% of values observed serum 24 h intake. CONCLUSIONS: administration EC, neither proportion sperm, nor level was influenced by 1.5 mg LNG. did not impair cervical mucus either because viable spermatozoa found genital tract 36–60 coitus 24–48 mechanism action as EC remains unknown.

参考文章(35)
Zev Rosenwaks, John A. Rock, E. Y. Adashi, Reproductive endocrinology, surgery, and technology Lippincott-Ravan, c1996. ,(1996)
R. Koistinen, I. Leivo, M. Seppälä, E. M. Rutanen, M. Kämäräinen, U. Karvonen, M. Julkunen, Normal human ovary and ovarian tumors express glycodelin, a glycoprotein with immunosuppressive and contraceptive properties American Journal of Pathology. ,vol. 148, pp. 1435- 1443 ,(1996)
Jie Shen, Yan Che, Emily Showell, Ke Chen, Linan Cheng, Interventions for emergency contraception Cochrane Database of Systematic Reviews. ,vol. 8, pp. 0- 0 ,(2017) , 10.1002/14651858.CD001324.PUB5
M. Williams, L.A. Thompson, T.C. Li, A. Mackenna, C.L.R. Barratt, I.D. Cooke, Uterine flushing: a method to recover spermatozoa and leukocytes Human Reproduction. ,vol. 8, pp. 925- 928 ,(1993) , 10.1093/OXFORDJOURNALS.HUMREP.A138168
P. Bielfeld, M. Graf, R. S. Jeyendran, L. J. D. Zaneveld, No change in acrosome reaction of human spermatozoa during storage in cervical mucus Andrologia. ,vol. 24, pp. 83- 86 ,(2009) , 10.1111/J.1439-0272.1992.TB02615.X
Marta Durand, Ma del Carmen Cravioto, Elizabeth G Raymond, Ofelia Durán-Sánchez, Ma De la Luz Cruz-Hinojosa, Andrés Castell-Rodrı́guez, Raffaela Schiavon, Fernando Larrea, On the mechanisms of action of short-term levonorgestrel administration in emergency contraception Contraception. ,vol. 64, pp. 227- 234 ,(2001) , 10.1016/S0010-7824(01)00250-5
William S.B. Yeung, Kai-Fai Lee, Riitta Koistinen, Hannu Koistinen, Markku Seppala, P.C. Ho, Philip C.N. Chiu, Roles of glycodelin in modulating sperm function. Molecular and Cellular Endocrinology. ,vol. 250, pp. 149- 156 ,(2006) , 10.1016/J.MCE.2005.12.038
Ariel Fuentes, Alberto Palomino, Alejandra Espinoza, Paulina Kohen, Sirpa Ranta, Helena von Hertzen, Luigi Devoto, Pharmacokinetics and endometrial tissue levels of levonorgestrel after administration of a single 1.5-mg dose by the oral and vaginal route Fertility and Sterility. ,vol. 84, pp. 46- 51 ,(2005) , 10.1016/J.FERTNSTERT.2005.01.106
Vesa Nikkanen, Karl-Ove Söderström, Sari Tuusa, Ulla-Marjut Jaakkola, Effect of local epididymal levonorgestrel on the fertilizing ability of male rat, a model for post-testicular contraception Contraception. ,vol. 61, pp. 401- 406 ,(2000) , 10.1016/S0010-7824(00)00125-6
Horacio B Croxatto, Luigi Devoto, Marta Durand, Enrique Ezcurra, Fernando Larrea, Carlos Nagle, Maria Elena Ortiz, David Vantman, Margarita Vega, Helena von Hertzen, Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature Contraception. ,vol. 63, pp. 111- 121 ,(2001) , 10.1016/S0010-7824(01)00184-6